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'Grey's Anatomy' Season 13 Spoilers: 4 Burning Questions We Have Before Premiere

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(Photo : Getty Images/Frazer Harrison) What will happen to the character in "Grey's Anatomy" season 13, episode 1?

"Grey's Anatomy" season 13 will premiere in September, and viewers are expecting some of the unfinished storylines from last season to finally be addressed.

Here are 4 burning questions we want answered in the premiere episode of "Grey's Anatomy" season 13.

Will Alex be able to accept Jo's past?

Alex Karev (Justin Chambers) and Jo Wilson (Camilla Luddington) have been in a relationship for quite some time now. However, Jo just couldn't accept Alex's proposal no matter how many times he already asked her.

In the premiere episode, it is expected that Jo will finally reveal the real reason why she couldn't say yes to Alex. Will the latter be able to accept it and choose to stay in a relationship with her?

Will Meredith and Maggie have a falling out?

Meredith Grey (Ellen Pompeo) and Nathan Riggs (Martin Henderson) hooked up with each other a few times in season 12. It was only in the finale that Meredith knew about Maggie's (Kelly McCreary) feelings for Nathan.

In the premiere, it is also expected that Meredith will come clean to Maggie about what happened to her and Nathan. However, how Maggie will react is something that's very difficult to predict.

Will Amelia and Owen decide to have a child?

Amelia Shepherd (Caterina Scorsone) and Owen Hunt (Kevin McKidd) recently tied the knot. The couple may talk about having children, but it is unclear whether or not they will actually decide to have one soon.

In the past, Amelia and Owen lost their baby when they were still dating their respective partners. This means that having a child together may be challenging and traumatizing for them.

Will April and Jackson get back together?

April Kepner (Sarah Drew) and Jackson Avery (Jesse Williams) recently bonded over the arrival of their baby. Will the bundle of joy be enough motivation for them to get back together?

"Grey's Anatomy" season 13 will premiere on ABC on Sept. 22 at 8 p.m. ET.

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